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| | Edited Special Issues of Journal |
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251. Zhang, W. Co-Guest Editor, ChemistryOpen, special issue on Multicomponent Reactions, 2023.
250. Zhang, W. Co-Guest Editor, Green and Highly Efficient One-Pot Synthesis and Catalysis Molecules 2023.
249. Zhang, W. Co-Guest Editor, Interdisciplinary Routes in Green Synthesis iScience 2022.
248. Zhang, W. Guest Editor, Sustainable Synthesis Molecules 2019.
247. Zhang, W. Co-Guest Editor, Products and Bionanotechnology for Cancer and Disease Treatment Biomolecules 2019.
246. Zhang, W. Guest Editor, Fluorous Chemistry QSAR Comb. Sci. 2006, 25, 675-806. |
| Books |
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245. Pot, Atom, and Step economy (PASE) Synthesis, Zhang, W.; Yi, W.-B., Springer, 2019.
244. Green Techniques for Organic Synthesis and Medicinal Chemistry, 2nd edition, Zhang, W.; Cue, B. W. Eds., Wiley, 2018.
243. Green Techniques for Organic Synthesis and Medicinal Chemistry, Zhang, W.; Cue, B. W. Eds., Wiley, 2012.
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| Book Chapters |
242. Nath, A.; Zanuy, A.; Zhang, W. "Synthesis of Spirooxindoles by [3+2] Cycloadditions" in Spirooxindole: Chemistry, Synthesis, Characterization and Biological Significance, Patel, G.; Shah, V. R.; Deshmukh, K.; Anh, T. Eds, Elsevier, MS submitted.
241. Zhang, W. "Green synthesis of heterocycles via MCRs" in Multicomponent Reactions towards Heterocycles, Van der Eycken, E. Eds, Wiley, 2022, p163-209.
240. Yi, W.; Song, Z.; Liu, J.; Mumtaz, Y.; Zhang, W. "Trifluoromethylthiolation of Aromatic and Heteroaromatic Compounds" in Emerging Fluorinated Motifs. Synthesis, Properties and Applications, Cahard, D.; Ma, J. Eds, Wiley-VCH, 2020, pp343-371.
239. Zhang, W. "One-pot Organic Reactions" in Green Synthetic Processes and Procedures, Ballini, R. Ed, RSC, pp20-38.
238. Zhang, W. "Light Fluorous Synthesis" in Green Techniques for Organic Synthesis and Medicinal Chemistry, 2nd Edition, Zhang, W.; Cue, B. W. Eds., Wiley, Chichester, 2018, pp509-538.
237. Zhang, W. "Fluorous Linker-Enabled Organic Synthesis" in Comprehensive Organic Synthesis, 2nd Edition, Molander, G.; Knochel, P. Eds, Elsevier, 2014, pp315-329.
236. Zhang, W. "Fluorous Synthesis" in Green Techniques for Organic Synthesis and Medicinal Chemistry, Zhang, W.; Cue, B. W. Eds. Wiley, 2012, pp443-468.
235. Zhang, W. "Fluorous Organocatalysis" in Fluorous Chemistry, Top. in Curr. Chem. Horvath, I. Ed. Springer, 2012, pp175-190.
234. Zhang, W. "Fluorous Linker-facilitated Synthesis of Biologically Interesting Molecules" in Modern Chemoselective Tools for the Synthesis of Complex Bioactive Molecules, Cossy, J.; Arseniyadis, S. Eds. Wiley, 2012, pp335-357.
233. Zhang, W.; Lu, Y. "Fluorous Synthesis of 3-Aminoimidazo[1,2-a]-pyridine/pyrazine Library" in Wiley Series on Solid-Phase Organic Synthesis, Volume 2: Solid-Phase Palladium Chemistry; Scott, P. Ed. Wiley, 2012, pp51-57.
232. Mudhoo, A.; Sharma, S. K.; Zhang, W. "Green Chemistry and Engineering: A Versatile Research Perspective", in Green Chemistry and Green Engineering Research; Mudhoo, A.; Sharma, S. K. Eds., CRC Press Taylor & Francis, 2010, pp1-52.
231. Zhang, W. "Fluorous Linkers" in Linker Strategies in Solid-Phase Organic Synthesis, Scot, P. Ed.; Wiley, 2009, pp553-376.
230. Zhang, W. "Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products" in Fluorine in Bioorganic and Medicinal Chemistry; Ojima, I. Ed.; Wiley-Blackwell, 2009, pp335-359.
229. Zhang, W. "Fluorous Chemistry for Synthesis and Purification of Biomolecules: Peptides, Oligosacchrades, Glycopeptides, and Oligonucleotides" in ACS Symposium Series: Current Fluoroorganic Chemistry. New Synthetic Directions, Technologies, aterials pand Biological Application; Mikami, K.; Soloshonok, V. Eds.; Oxford University Press, 2006, pp207-220.
228. Zhang, W. "Microwave-Enhanced High-Speed Fluorous Synthesis" in Microwave Methods in Organic Synthesis; Topics curr. Chem. vol. 266, Larhed, M.; Olofsson, K. Eds.; Springer, 2006, pp145-166.
227. Zhang, W. "Fluorous Protecting Groups and Tags" in Handbook of Fluorous Chemistry; Gladysz, J. A.; Curran, D. P.; Horvath, I. Eds. Wiley-VCH, 2004, pp222-236.
226. Zhang, W. "Synthetically Useful Radical Rearrangements, Ring Expansions" in Radical in Organic Synthesis, vol. 2, Renaud, P.; Sibi, M. P. Eds.; Wiley-VCH, Weinheim, 2001, pp234-245.
| Reviews, Accounts and other Invited Articles |
225. Liu, X.; Huan, C.; Zhang, X.; Zhang, W. "Difluorocarbene-enabled synthesis of 18F-radiotracers in positron emission tomography" J. Florine Chem., manuscript submitted.
224. Zhang, X.; Ma, X.; Zhang, W. "Decarboxylative 1,3-Dipolar Cycloadditions of Amino Acid-derived non-Stabilized Azomethine Ylides for Multicomponent, One-pot and Multistep Reactions for the Synthesis of Heterocyclic Compounds" Beilstein J. Org. Chem. 2023, in press.
223. Wang, N.; Mei, H.; Dhawan, G.; Zhang, W.; Han, J. Soloshonok, V. A. "New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine" Molecules 2023, 28, 3651.
222. Ma, X.; Zhang, Q.; Zhang, W. "Remote Radical 1,3-, 1,4-, 1,5-, 1,6- and 1,7-Difunctionalization Reactions" Molecules 2023, 28, 3027.
221. Hooshmand S. E.; Zhang, W. "Ugi Four-component Reactions Using Alternative Reactants" Molecules 2023, 28, 1642.
220. Saito, T.; Awad, J. M.; Zhang, W. "Synthetic Studies towards Tetracyclic Diquinane Lycopodium Alkaloids Magellanine, Magellaninone and Paniculatine" Molecules 2023, 28, 1501.
219. Zhi, S.; Yao, H.; Zhang, W. "Difunctionalization of Dienes, Enynes and Related Compounds via Sequential Radical Addition and Cyclization Reactions" Molecules 2023, 28, 1145.
218. Dhawan, G.; Zhang, W.; Soloshonok, V. A.; Han, J. "Fluorine-containing Pharmaceuticals Approved by the FDA in 2021. Synthesis and biological activity" Chinese Chem Lett. 2023, 34, 107578.
217. Ma, X.; Zhang, W. "New developments on one-pot multistep synthesis" iScience 2022, 25, 105005.
216. Huang, X.; Zhang, W. "Recyclable fluorous cinchona organocatalysts for asymmetric synthesis of biologically interested compounds" (Feature Article) Chem. Commun. 2021, 2021, DOI: 10.1039/D1CC03722F
215. Yu, Y.; Liu, A.; Dhawan, G.; Mei, H.; Zhang, W.; Izawa, K.; Soloshonok, V. A.; Han, J. "Fluorine-containing Pharmaceuticals Approved by the FDA in 2020" Chinese Chem. Lett. 2021, in press.
214. Ma, X.; Zhi, S.; Zhang, W. "Recent Development on Five-Component Reactions" Molecules 2021, 26, 1986.
213. Yao, H.; Hu, W.; Zhang, W. "Difunctionalization of Alkenes and Alkynes via Intermolecular Radical and Nucleophilic Additions" Molecules 2021, 26, 105.
212. Mei, H.; Hu, W.; Zhang, W.; Konno, H.; Moriwaki, H.; Izawa, K.; Soloshonok, V. A.; Han, J. "Tailor-made Amino Acid-derived Pharmaceuticals Approved by the FDA in 2019" Amino Acids 2019, 52, 1227-1261.
211. Zhi, S.; Ma, X.; Zhang, W. "Consecutive multicomponent reactions for complex molecules with high synthetic efficiency" Org. Biomol. Chem. 2019, 17, 7632-7650.
210. Zhang, X.; Zhang, W. "PASE Synthesis of Heterocycles Through [3+2] Cycloaddition-Initiated Reactions" Curr. Opin. Green Sustainable Chem. 2018, 11, 65-69.
209. Dhawan, G.; Zhang, W. "A Brief Overview of Chemical and Biosynthesis of Vanillin Flavor" J. Shanghai Inst. Tech. (Nat. Sci.) 2017, 17, 102-111.
208. Pan, X.-Q.; Zou, J.-P.; Yi, W.-B.; Zhang, W. "Recent Advances in Sulfur- and Phosphorous-centered Radical Reactions for the Formation of S-C and P-C Bonds" Tetrahedron Reports, Tetrahedron 2015, 717481-7529.
207. Jiang, Z.-X.; Zhi, S. Zhang, W. "Recent Progresses on Fluorous Synthesis of Biologically Interested Compounds" Mol. Divers. 2014, 18, 203-218.
206. Yi, W.-B; Ma, J.-J.; Jiang, L.-Q.; Cai, C.; Zhang, W. "Synthesis and Uses of Fluorous and Highly Fluorinated Macrocyclic and Spherical Molecules" J. Fluorine Chem. 2014, 157, 84-105.
205. Huang, Y. Zhang, W. "Magnetic nanoparticle-supported organocatalysis" Green Process. Synth. 2013, 2, 603-609.
204. Zhang, W. "1,3-Dipolar Cycloaddition-Based Synthesis of Diverse Heterocyclic Scaffolds" Chem. Lett. 2013, 42, 676-681.
203. Zhang, W. "Laboratory profile of the Green Organic and Medicinal Chemistry at the University of Massachusetts Boston" Green Processing and Synth. 2012, 1, 291-293.
202. Kadam, A.; Ding, S.; Bipani, B.; Zhang, W. "Convertible Fluorous Sulfonate Linker for the Synthesis of HeterocyclicScaffolds" J. Chinese Chem. Soc. 2011, 58, 575-582 .
201. Zhang, W. "Fluorous Organocatalysis - A Green Approach for Asymmetric Synthesis" Chimica Oggi (Chemistry Today), 2011, 29 (3), 32-34..
200. Kadam, A.; Zhang, Z.; Zhang, W. "Microwave-Assisted Fluorous Multicomponent Reactions - A Combinatorial Chemistry Approach for Green Organic Synthesis" Curr. Org. Syn. , 2011, 8, 295-309.
199. Zhang, W. "Review of Microwave Heating as a Tool for Sustainable Chemistry" J. Am. Chem. Soc. 2011, 133, 3218.
198. Dolle, R, E.; Bourdonnec, B. L.; Worm, K.; Morales, G. A.; Thomas, C. J.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009" J. Comb. Chem., 2010, 12, 765-806
197. Dolle, R. E.; Bourdonnec, B. L.; Goodman, A. J.; Morales, G. A.; Thomas, C. J.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2008" J. Comb. Chem. 2009, 11, 739-790.
196. Zhang, W. "Green Chemistry Aspects of Fluorous Techniques - Opportunities and Challenges for Small-Scale OrganicSynthesis" Critical review, Green Chem. 2009, 11, 911-920.
195. Pan, X.-Q.; Zou, J.-P.; Zhang, W. Manganese(III)-Promoted Reactions for Formation of Carbon-Heteroatom Bonds, Mol. Diversity 2009, 13, 421-438.
194. Zhang, W. "Fluorous Linker Facilitated Chemical Synthesis" Chem. Rev. 2009, 109, 749–795.
193. Cai, C.; Yi, W.-B.; Zhang, W.; Shen, M.-G.; Hong, M.; Zeng, L. Y. "Fluorous Lewis Acids and Phase Transfer Catalysts" Mol. Diversity, 2009, 13, 209-239.
192. Dolle, R. E.; Bourdonnec, B. L.; Goodman, A. J.; Morales, G. A.; Thomas, C. J.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2007" J. Comb. Chem. 2008, 10, 703-804.
191. Zhang, W.; Cai, C. "New Chemical and Biological Applications of Fluorous Technologies" Chem. Commun. Feature Article, 2008, 5686-5694.
190. Zhang, W. "Fluorinated Stationary Phases for HPLC Analysis and Separations J. Fluorine Chem. 2008, 129, 910-919.
189. Zhang, W. "Fluorous Silica Gel" in Encyclopedia of Reagents for Organic Synthesis, article RN00870, Crich, D. Ed. Wiley, 2007.
188. Dolle, R. E.; Bourdonnec, B. L.; Goodman, A. J.; Morales, G. A.; Salvino, J. M.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2006" J. Comb. Chem. 2007, 9, 855-902.
187. Zhang, W. "Fluorous-Enhanced Multicomponent Reactions for Making Drug-Like Library Scaffolds" Comb. Chem. High Throughput Screening 2007, 10. 219-229.
186. Zhang, W.; Curran, D. P. "Synthetic applications of fluorous solid-phase extraction (F-SPE)" Tetrahedron Reports No. 777, Tetrahedron 2006, 62, 11837-11865. Tetrahedron Top 50 most Cited Articles (2005-2008) Award.
185. Zhang, W. "Fluorous Chemistry: From Biphasic Catalysis to High-Throughout Synthesis of Small Molecules and Separation/Immobilization of Biomolecules" Editorial, QSAR Comb. Sci. 2006, 25, 679.
184. Mikulan, K.; Yu, M.; Zhang, W. "FluoroFlash Silica Gel for Solid-Phase Extraction and HPLC Applictions" Nature Methods, Application Notes 2006.
183. Zhang, W. "Microwave-Enhanced Fluorous Synthesis" Chimica Oggi (Chemistry Today) 2005, 23 (3):XI-XIII.
182. Zhang, W. "Fluorous Synthesis of Heterocyclic Systems" Chem. Rev. 2004, 104, 2531-2556.
181. Zhang W. "Fluorous Tagging Strategy for Solution-Phase Synthesis of Small Molecules, Peptides and Oligosaccharides" Curr. Opin.Drug Discov. Devel. 2004, 7, 784-797.
180. Zhang, W. "Fluorous Protecting Groups for Solution-Phase Library Synthesis" Specialty Chemicals Magazine 2004, 25 (5), 30-32.
179. Zhang, W."Fluorous Mixture Synthesis(FMS) for Enantiomers, Diastereomers, and Compound Libraries" Arkivoc 2004 (i),101-109.
178. Zhang, W. "Recent Advance in the Synthesis of Biologically Interesting Heterocycles by Intramolecular Aryl Radical Reactions" Curr. Org. Chem. 2004, 8, 757-780.RN00425, Wipf, P. Ed. Wiley, 2004.
177. Chen, C. H-T.; Zhang, W. "Fluorous Thiol" Encyclopedia of Reagents for Organic Synthesis, article RN00425, Wipf, P. Ed. Wiley, 2004.
176. Lu, Y.; Zhang, W. "Fluorous TIPS Triflate" Encyclopedia of Reagents for Organic Synthesis, article RN00424, Wipf, P. Ed. Wiley, 2004.
175. Zhang, W.; Chen, C. H.-T. "Fluorous Scavenging" in Handbook of Fluorous Chemistry; Gladysz, J. A.;Curran, D. P.; Horvath, I. T. Eds. Wiley-VCH, 2004, pp473-474.
174. Zhang, W. "Fluorous Scavengers for Solution-Phase Synthesis" The Worldwide PharmaChem Directory, 2003, pp18-20.
173. Zhang, W. "Fluorous Technologies for Solution-Phase High-Throughput Organic Synthesis" Tetrahedron Reports No. 640, Tetrahedron 2003, 59, 4475-4489. Tetrahedron 50 Most Cited Paper (2004-2007) Award.
172. Zhang, W. "Fluorous Mixture Syntheses (FMS)" Chimica Oggi (Chemistry Today) 2003, (3/4), 22-24.
171. Zhang, W. "Discovery and Development of Cyclobutanone-Based Ring Expansion and Annulation Reactions" Curr. Org. Chem. 2002, 6, 1015-1029.
170. Zhang, W. "Intramolecular Free Radical Conjugate Additions" Tetrahedron Reports No. 580, Tetrahedron 2001, 57, 7237-7262.
169. Dowd, P.; Zhang, W. "Free Radical Mediated Ring Expansion and Related Annulations" Chem. Rev. 1993, 93, 2091-2115.
| Original Research Papers |
|
168. Lee, B.; Nanishi, E.; Awad, J. M.; Saito, Y.; Boriello, F.; Dong, D.; Kelly, A., Walker, K.; Cheng, W. K.; Brightman, S.; Sharma, P.; Vieira, D.; Ryff, K.; O’Meara, T. R.; Chew, K.; Sweitzer, C.; Van Haren, S.; Pettengill, M.; Seo, H.-S.; Dhe-Paganon, S.; Zhang. W.; Levy, O.; Dowling, D. J. "Discovery of a TLR3 Small Molecule Agonist Adjuvant" MS submitted.
167. Zhang, W.; Zheng, W.; Zuo, G.; Li, X.; Zhang, X.; Zhang, W. "One-pot Mannich/aza-Wittig/deaminative aromatization reactions for the synthesis of 1,2,3,4-tetrahedronacridines and cyclohepta[b]quinolines" New J. Chem. 2023, 47, 220-223.
166. Zhang, X.; Ma, X.; Qiu, W.; Awad, J.; Zhang, W. "Double [3+2] cycloadditions for diastereoselective synthesis of spirooxindole-pyrrolizidines" Green Process Synth. 2022, 11, 1128-1135.
165. Zhao, H.; Leng, X.; Zhang, W.; Shen, Q. "[Ph4P]+[Cu(CF2H)2]?: A Powerful Difluoromethylating Reagent Inspired by Mechanistic Investigation" Angew. Chem. Int. Ed. 2022, 61, e202210151.
164. Li, C.-K.; Tao, Z.-K.; Shoberu, A.; Zhang, W.; Zou, J.-P. "Copper-Catalyzed Cross-Coupling of Alkyl and Phosphorus Radicals for C(sp3)-P Bond Formation" Org. Lett. 2022, 24, 6083-6087.
163. Zhang, X.; Liu, M.; Zhan, D.; Kaur, M.; Jasinski, J. P.; Zhang, W. "Three-Component [3+2] Cycloaddition for Regio- and Diastereoselective Synthesis of Spirooxindole-Pyrrolidines" New J. Chem. 2022, 46, 3866-3870.
162. Zhang, X.; Liu, L.; Murray, S. A.; Qiu, W.; Ma, X.; Evans, J.; Jasinski, J. P.; Zhang, W. "Pseudo Five-Component Reaction for Diastereoselective Synthesis of Symmetric Bispiro[oxindole-pyrrolidine]s", J. Org. Chem.2021, 86, 17395-17403.
161. Zhang, W.; Li, Y.; Zhou, H.; Su, X.; Zhang, X..; Zhang, W. "One-pot, Two-step Synthesis of 3,4-Dihydroquinazoline-2(1H)-thiones from o-Azidobenzenealdehydes, Aryl amines and Carbon difulfide" Tetrahedron Lett. 2021, 62, 153361.
160. Tao, Z.-K.; Li, C.-K.; Li, J-a. Shoberu, A.; Zhang, W.; Zou, J.-P. "Copper-Catalyzed Vicinal Cyano-, Thiocyano-, and Chlorophosphorylation of Alkynes: A Phosphinoyl Radical-Initiated Approach for Difunctionalized Alkenes" Org. Lett. 2021, 23, 4342-4347.
159. Muthengi, A.; Wimalasena, V. K.; Yosief, H. O.; Bikowitz, M. J.; Li, D.; Gaieb, Z.; Dhawan, G.; Liu, S.; Erickson, J.; Schonbrunn, E.; Amaro, R. E.; Qi, J.; Zhang, W. "Development of Dimethylisoxazole-attached Imidazo[1,2-a]pyridines as Potent and Selective CBP/P300 Inhibitors" J. Med. Chem. 2021, 64, 5787-5801.
158. Ma, X.; Qiu, W.; Liu, L.; Zhang, X.; Zhang, Q.; Awad, J.; Evans, J.; Zhang, W. "Synthesis of Tetrahydropyrrolothiazoles through One-pot and 4-Component N,S-acetalation and Decarboxylative [3+2] Cycloaddition" Green Syn. Catal.2021, 2, 74-77.
157. Yang, G.; Liu, Y.; Wang, L.; Zhang, Y.; Ma, X.; Zahng, W. "Diastereoselective Synthesis of Hexahydropyrrolo[2,1-a]isoquinolines by [3+2] Cycloaddition and Cyclative Heck Alkyne Hydroarylation" Tetrahedron Lett. 2021, 62, 152859.
156. Zhao, H.; Lu, C.; Herbert, S.; Zhang, W.; Shen, Q. "Difluoromethylation of Alkyl Bromides and Iodides with TMSCF2H under Mild Conditions" J. Org. Chem.2021, 86, 2854-2865.
155. Zhang, X.; Ma, X.; Qiu, W.; Awad, J. Evans, J.; Zhang, W. "One-pot Mannich, Aza-Wittig and Dehydrofluorinative Aromatization Reactions for Direct Synthesis of 2,3-Disubstituted 4-Aminoquinolines" Adv. Syn. Catal.2020, 362, 5513-5517.
154. Zhou, D.; Hayashi, T.; Jean, M.; Kong, W.; Fiches, G.; Biseas, A.; Liu, S.; Yosief, H. O.; Zhang, X.; Bradner, J. Qi, J.; Zhang, W.; Santoso, N.; Zhu, J. "Inhibition of Polo-like kinase 1 (PLK1) facilitates the elimination of HIV-1 viral reservoirs in CD4+ T cells" Sci. Adv. 2020, 6, eaba1941.
153. Ma, X.; Meng, S.; Zhang, X.; Zhang, Q.; Yan, S.; Zhang, Y.; Zhang, W. "Synthesis of Pyrrolidinedione-Fused Hexahydropyrrolo[2,1-A]Isoquinolines via Three-Component [3+2] Cycloaddition Followed by One-Pot N-Allylation and Intramolecular Heck Reactions" Beilstein J. Org. Chem.2020,16, 1225-1233.
152. Zhao, H.; Herbert, S.; Kinzel, T.; Zhang, W.; Shen, Q. "Two Ligands Transfer from Ag to Pd: En Route to (SIPr)Pd(CF2H)(X) and its Application in One-pot C-H Borylation/Difluoromethylation" J. Org. Chem.2020, 85, 3596-3604.
151. Ma, X.; Zhang, X.; Awad, J. M.; Xie, G.; Qiu, W.; Muriph, R.E.; Zhang, W. "Sequential Decarboxylative [3+2] Cycloaddition and aza-Wittig Reactions for Diastereoselective Synthesis of Tetrahydro-pyrroloquinazolines and Tetrahydro-pyrrolobenzodiazepines" Tetrahedron Lett. 2020, 61, 151392.
150. Zhang, T.; Pan, J.; Duan, J.; Wu, J. Zhang, W.; Wu, F. "Nickel-Catalyzed Radical Bifunctionalization of Alkenes with 2,2-Difluoro-2-iodo-1-phenylethanone for Iododifluoromethyl Ketones" ChemCatChem 2019, 11, 5778-5782.
149. Ma, X.; Zhang, X.; Xie, G.; Awad, J. M.; Zhang, W. "One-pot Synthesis of Tetrahydroepimino-benzo[b]azocine through [3 + 2] Cycloaddition and Aza-Wittig Reactions" Tetrahedron Lett. 2019, 60, 151127.
148. Timm, N.; Han, Y.; Liu; S.; Yosief, H. O.; Garcia, H. D.; Bei, Y.; Klironomos, F.; MacArthur, I. C.; Szymansky, A.; Bardinet, V.; Dohna, C.; Kunkele, A.; Rolff, J.; Hundsdorfer, P.; Lissat, A.; Seifert, G.; Eggert, A.; Schulte, J. H.; Zhang, W.; Henssen, A. G. "Small-Molecule Dual PLK1 and BRD4 Inhibitors Are Highly Active Against Preclinical Models of MYC/N-Driven Pediatric Tumors" Transl. Oncol.2019, 13, 221-232.
147. Ma, X.; Zhang, X.; Awad, J. M.; Xie, G.; Qiu, W.; Zhang, W. "One-pot Synthesis of Tetrahydro-pyrrolobenzodiazepines and Tetrahydro-pyrrolobenzodiazepinons Through Sequencial 1,3-Dipolar Cycloaddition/N-Alkylation (N-Acylation)/Staudinger/Aza-Wittig Reactions" Green Chem. 2019,21, 4489-4494.
146. Jia, L.; Gui, B.; Takai, T.; Feng, C.; Bai, X.; Liu, S.; Zhang, X.; Zhang, W. Kibel, K. "Selective Targeting of PARP2 Inhibits Androgen Receptor Signaling and Prostate Cancer Growth Through Disruption of FOXA1 Function" Proc. Natl. Acad. Sci.2019, 116, 14573-14582.
145. Kong, W.; Hayashi, T.; Fiche, G.; Xu, Q.; Li, M. Z.; Que, J.; Liu, S.; Zhang, W.; Qi, J.; Santoso, N.; Elledge, S.; Zhu, J. "Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions" Genomics Proteomics Bioinformatics 2019, 17, 319-331.
144. Muthengi, A. Erickson, J.; Muriph, R. E.; Zhang, W. "[3+2] Cycloaddition and Cascade Radical Reaction for the Synthesis of Trifluoromethylated Tetrahydrobenzodiazepin-3-ones" J. Org. Chem. 2019, 83, 5927-5935.
143. Zhang, X.; Qiu, W.; Evans, J.; Kaur, M.; Jasinski, J. P.; Zhang, W. "Double 1,3-Dipolar Cycloadditions of Two Nonstabilized Azomethine Ylides for Polycyclic Pyrrolidines" Org. Lett. 2019,21, 2146-2179.
142. Ma, X.; Zhang, X.; Qiu, W.; Zhang, W.; Wan, B.; Evans, J. Zhang, W. "One-pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3+2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-free Click Reactions" Molecules 2019, 24, 601.
141. Zhang, X.; Ma, X.; Qiu, W.; Evans, J.; Zhang, W. "Cascade Knoevenagel and Aza-Wittig Reactions for the Synthesis of Substituted Quinolines and Quinolin-4-ols" Green Chem. 2019,21, 3349-354.
140. Liu, M.; Zhang, X.; Huang, X.; Dhawan, G.; Evans, J.; Kaur, M.; Jasinski, J. P.; Zhang, W. "Recyclable Organocatalysts for One-pot Asymmetric Synthesis of Dihydrofuranone and Tetrahydropyranone Spirooxindoles" Eur. J. Org. Chem. 2019, 150-155.
139. Jiang, L.; Ya, Q.; Wang, R.; Ding, T.; Yi, W.; Zhang, W. "Trifluoromethanesulfinyl Chloride for Electrophilic Trifluoromethythiolation and Bifunctional Chlorotrifluoromethythiolation" Chem. Eur. J. 2018, 24, 18749-18756.
138. Zhang, X.; Qiu, W.; Ma, X.; Evans, J.; Kaur, M.; Jasinski, J. P.; Zhang, W. "One-pot Double [3+2] Cycloadditions for Diastereoselective Synthesis of Pyrrolidine-based Polycyclic Systems" J. Org. Chem. 2018, 83, 13536-13542.
137. Zhang, W.; Zhang, X.; Ma, X.; Zhang, W. "One-pot Synthesis of Dihydroquinazolinethione-Based Polycyclic System" Tetrahedron Lett. 2018, 59, 3845-3847.
136. Huang, X.; Zhao, W.; Zhang, X.; Liu, M.; Vasconcelos, S. N. S.; Zhang, W. "One-pot Fluorination and Organocatalytic Robinson Annulation for Asymmetric Synthesis of Mono- and Difluorinated Cyclohexenones" Molecules 2018, 23, 2251.
135. Muthengi, A.; Zhang, X.; Dhawan, G.; Zhang, W.; Corsini, F.; Zhang, W. "Sequential [3+2] Cycloaddition and [5+n] Annulation Reactions for Modular Synthesis of Dihydrobenzoxazines, Tetrahydrobenzoxazepines and Tetrahydrobenzoxazocines" Green Chem. 2018, 20, 3134-3139.
134. Liu, S.; Yosief, H. O.; Dai, L.; Huang, H.; Dhawan, G.; Zhang, X.; Muthengi, A. M.; Roberts, J.; Buckley, D.; Wu, L.; Bradner, J.; Qi, J.; Zhang, W. "Structure-guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors" J. Med. Chem. 2018, 61, 7785-7795.
133. Li, C.K.; Olamiji, O.O.; Zhang, P. Z.; Shoberu, A.; Zou, J.-P.; Zhang, W. "Mn(OAc)3-mediated Radical Alkoxycarbonylation of Indoles, Pyrimidinones and Pyridinones" Synthesis, 50, 2968-2973.
132. Jiang, L.; Ding, D.; Yi, W.; Zeng, X.; Zhang, W. "Fluoroalkylsulfonyl Chlorides-promoted Vicinal Chlorofluoroalkylthiolation of Alkenes and Alkynes" Org. Lett. 2018, 20, 2236-2240.
131. Zhang, X.; Liu, M.; Qiu, W.; Evans, J.; Kaur, M.; P. Jasinski, J. P.; Zhang, W. "One-pot Synthesis of Polycyclic Spirooxindoles via Montmorillonite K10-Catalyzed C-H Functionalization of Cyclic Amines" ACS Sustainable Chem. Eng. 2018, 6, 5574-5579.
130. Tao, Z.-K.; Li, C.-K.; Zhang, P.-Z.; Zhang L.; Shoberu, A.; Zou, J.-P.; Zhang, W. "Phosphinoyl Radical-initiated 1,2-Bifunctional Thiocyanophosphinoylation of Alkenes" J. Org. Chem. 2018, 83, 2418-2424.
129. Zhang, X.; Liu, M.; Zhang, W.; Legris, M. Zhang, W. "Synthesis of a-Trifluoromethyl Pyrrolidines via A Three-component and Decarboxylative [3+2] Cycloaddition Reaction" J. Fluorine Chem. 2017, 204, 18-20.
128. Zhang, P.-Z.; Zhang L.; Li, J.-A.; Shoberu, A.; Zou, J.-P.; Zhang, W. "Phosphinoyl Radical-initiated Vicinal Cyanophosphinoylation of Alkenes" manuscript submitted" Org. Lett. 2017, 19, 5537-5540.
127. Li, J.-A.; Zhang, P.-Z.; Liu, K.; Shoberu, A.; Zou, J.-P.; Zhang, W. "Phosphinoyl Radical-initiated 1,2-Aminophosphinoylation of Alkenes" Org. Lett., 2017, 19, 4704-4706.
126. Zhang, X.; Dhawan, G.; Muthengi, A.; Liu, S.; Wang, W.; Legris, M; Zhang, W. "One-pot and Catalyst-free Synthesis of Pyrroloquinolinediones and Quinolinedicarboxylates" Green Chem. 2017, 19, 3851-3855.
125. Huang, H.; Liu, S.; Jean, M.; Huang, H.; Feeney, C.; Hayashi, T.; Kong, W.; Simpson, S.; Sanchez, I. R.; Zhang, X.; Yosief, H. O.; Miao, H.; Que, J.; Kobie, J.; Bradner, J.; Netty Santoso, N.; Zhang, W.; Zhu, J. "A Novel Bromodomain Inhibitor Reverses HIV-1 Latency Through Specific Binding with BRD4 to Promote Tat and P-TEFb Association" Front. Microbiol. 2017, article 1035.
123. Yan, Q.; Jiang, L.; Yi, W.; Liu, Q.; Zhang, W. "Metal-free Difluoromethylthiolation, Trifluoromethylthiolation, and Perfluoroalkylthiolation with HCF2SO2Na, CF3SO2Na or RfSO2Na" Adv. Synth. Catal. 2017, 359, 1919-1926.
122. Huang, X.; Liu, M.; Jasinski, J. P.; Peng, B.; Zhang, W. "Recyclable Organocatalysts for the One-pot Asymmetric Synthesis of 2-Fluorocyclohexanols Bearing Six Contiguous Stereocenters" Adv. Synth. Catal. 2017, 359, 2471-2480.
121. Zhang, P.-Z.; Li,J.-A.; Zhang, L.; Shoberu, A.; Zou,J.-P.; Zhang, W. "Metal-free Radical C-H Methylation of Pyrimidinones and Pyridinones with Dicumyl Peroxide" Green Chem. 2017, 19, 919-923.
120. Koblan, L. W.; Buckley, D. L.; Ott, C. J.; Fitzgerald, M. E.; Ember, S. J. W.; Zhu, J.-Y.; Liu, S.; Roberts, J. M.; Remillard, D.; Vittori, S.; Zhang, W.; Schonbrunn, E.; Bradner, J. E. "Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET" ChemMedChem, 2016, 11, 2575-2581.
119. Song, Z.; Huang, X.; Yi, W.-B.; Zhang, W. "One-pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridines" Org. Lett., 2016, 182, 5640-5643.
118. Zhang, X.; Pham, K.; Liu, S.; Legris, M.; Muthengi, A.; Jasinski, J. P.; Zhang, W. "Stereoselective Synthesis of Fused-Tetrahydroquinazolines Through One-Pot Double [3+2] Cycloadditions Followed by [5+1] Annulation" Beilstein J. Org. Chem. 2016, 12, 2204-2210.
117. Qian, J.; Yi, W.; Huang, X.; Jasinski, J. P.; Zhang, W. "2,2-Difluoro-1,3-diketones As gem-Difluoroenolate Precusors for Asymmetric Aldol Addition with N-Benzyl Isatins" Adv. Synth. Catal. 2016, 358, 2811-2816.
116. Huang, X.; Liu, M.; Pham, K.; Zhang, X.; Yi W.-B.; Jasinski, J. P.; Zhang, W. "Organocatalytic One-pot Asymmetric Synthesis of Thiolated Spiro-gamma-lactam-oxindoles Bearing Three Stereogenic Centers" J. Org. Chem. 2016, 81, 6562-5369.
115. Yang, G.; Buhrlage, S.; Li, T.; Liu, X.; Chen, J.; Xu, L.; Tsakmaklis, N.; Chen, J.; Patterson, C. J.; Brown, J.; Castillo, J. J.; Zhang, W.; Zhang, X.; Liu, S.; Cohen, P.; Hunter, Z. R.; Gray, N.; Treon, S. P. "HCK Is a Survival Determinant Transactivated by Mutated MYD88, and A Direct Target of Ibrutinib" Blood, 2016, 127, 3237-3252.
114. Zhang, X.; Zhi, S.; Wang, W.; Liu, S.; Jasinski, J. P.; Zhang, W. "A Pot-economy and Diastereoselective Synthesis Involving Catalyst-free Click Reaction for Fused-triazolobenzodiazepines" Green Chem. 2016, 18, 2642-2646.
113. Huang, X.; Pham, K.; Yi, W.; Zhang, X.; Clamens C.; Hyatt, J. P.; Jasinsk, J. P.; Tayvah, U.; Zhang, W. "Recyclable Organocatalyst-promoted One-pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers" Adv. Synth. Catal. 2015, 357, 3820-3824.
112. Jiang, L.; Yi, W.-B.; Lu, G.; Cai, C.; Zhang, W. "Direct Trifluoromethylthiolation and Perfluoroalkylthiolation of SP2 C-H Bonds with NaSO2CF3 or NaSO2Rf" Angew. Chem. Int. Ed. 2015, 54, 14965-14969.
111. Urick, A.; Hawk, L.; Cassel, M.; Mishra, N.; Adhikari, N.; Liu, S.; Zhang, W.; Hall, J.; Pomerantz, W. "Dual Screening Of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules" ACS Chem. Biol. 2015, 10, 2246-2256.
110. Huang, X.; Pham, K.; Zhang, X.; Yi, W.-B.; Hyatt, J.; Tran, A. P.; Jasinski, J. P.; Zhang, W. "Recyclable Organocatalyst for One-pot Asymmetric Synthesis of Fluorinated 2-Piperidinones Bearing Four Contiguous Stereogenic Centres" RSC Advances 2015, 5, 71071-71075.
109. An, L.-T.; Cai, J. J.; Pan, X.-Q.; Chen, T.-M.; Zou, J.-P.; Zhang , W. "Ga(DS)3-Catalyzed Double Hydroarylation of Acetylenic Esters with Indoles for The Synthesis of Diindolyl Esters" Tetrahedron Lett. 2015, 56, 3996-3998.
108. Todoroki, K.; Ishii, Y.; Ide, T.; Min, J. Z.; Inoue, K.; Huang, X.; Zhang, W.; Hamashima, Y.; Toyo'oka, T. "Advanced Dress-up Chiral Columns; Increase of Lineup of Removable Chiral Stationary Phases for Enantioseparation of Chiral Carboxylic Acids" Anal. Chim. Acta 2015, 882, 101-111.
107. Pham, K.; Huang, X.; Zhang, W. "One-Pot Fluorination and Mannich Reactions of 1,3-Dicarbonyl Compounds" Tetrahedron Lett. 2015, 56, 1998-2000.
106. Qian, J.; Yi, W.; Huang, X.; Miao, Y.; Zhang, J.; Cai, C.; Zhang, W. "One-Pot Synthesis of 3,5-Disubstituted and Polysubstituted Phenols from Acyclic Precursors" Org. Lett. 2015, 17, 1090-1093.
105. McKeown, M.; Shaw, D.; Fu, H.; Liu, S.; Xu, X.; Marineau, J.; Huang, Y.; Zhang, X.; Buckley, D.; Lin, C.; Kadam, A.; Zhang, Z.; Blacklow, S.; Qi, J.; Zhang, W.; Bradner, J. "Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors" J. Med. Chem. 2014, 57, 9019-9027.
104. Vetter, M. L. Zhang, Z.; Liu, S.; Wang, J.; Cho, H.; Zhang, J.; Zhang, W.; Gray, N. S.; Yang, P. L. "Fluorescent Visualization of Src Using BODIPY-Dasatinib" ChemBioChem 2014, 15, 1317-1324.
103. Li, D.-P.; Pan X.-Q.; An, L.-T.; Zou, J.-P.; Zhang, W. "Manganese(III)-mediated Selective Diphenylphosphinoyl Radical Reaction of 1,4-Diphenylbutynes for the Synthesis of Phosphinoylated 3,4-Dihydronaphathalenes" J. Org. Chem. 2014, 79, 1850-1855.
102. Huang, S.-G.; Mao, H.-F.; Zhou, S.-F.; Zou, J.-P.; Zhang, W. "Recyclable Gallium(III) Triflate-Catalyzed [4+3] Cycloaddition for Synthesis of 2,4-Disubstituted-3H-Benzo[B][1,4]diazepines" Tetrahedron Lett. 2013, 54, 6178-6180.
101. Huang, X.; Yi, W.-B.; Ahad, D.; Zhang, W. "Recyclable Cinchona Alkaloid Catalyzed Asymmetric Michael Addition Reaction" Tetrahedron Lett. 2013, 54, 6064-6066.
100. Kadam, A.; Bellinger, S.; Zhang, W. "Atom- and Step-Economic Synthesis of Biaryl Substituted Furocoumarins, Furoquinolones and Furopyrimidines by Multicomponent Reactions and One-Pot Synthesis" Green Process. Synth. 2013, 2, 491-497.
99. Yi, W.-B.; Zhang, Z.; Huang, X.; Tanner, A.; Cai, C.; Zhang, W. "One-pot Fluorination and Asymmetric Michael Addition Promoted by Recyclable Fluorous Organocatalyst" RSC Advances 2013, 3, 18267-18270.
98. Lu, Q.; Huang, X.; Song, G.; Sun, C.-M.; Jasinski, J. P.; Keeley, A. C.; Zhang, W. "Sequential [3+2] and Intramolecular [4+2] Cycloadditions for Stereoselective Synthesis of Novel Polyheterocyclic Compounds" ACS Comb. Sci. 2013, 15, 350-355.
97. Wang , L.; Wang , J.-W.; Cui, A.-J.; Cai, X.-X.; Wan, Y.; Chen, Q.; He, M.-Y.; Zhang, W. "Regioselective 2,6-Dihalogenation of BODIPYs in HFIP and Preparation of Novel Meso-Alkyl Polymeric BODIPY Dyes" RSC Advances 2013, 3, 9219-9222.
96. Zhu, J.; Larman, H. B.; Gao, G.; Somwar, R.; Zhang, Z.; Laserson, U; Alberto Ciccia, A.; Pavlova, N.; Church, G.; Zhang, W.; Kesari, S.; Elledge, S. J. "Protein Interaction Discovery Using Parallel Analysis of Translated ORFs (PLato)" Nat. Biotechnol. , 31, 331-334.
95. Kadam, A.; Nguyen, M.; Kopach, M.; Richardson, P.; Gallou, F.; Wan, Z.-K.; Zhang, W. "Comparative Performance Evaluation and Systematic Screening of Solvents in a Range of Grignard Reactions" Green Chem. 2013, 15, 1880-1888.
94. Sun, W. B.; Ji, Y.-F.; Pan, X.-Q.; Zhou, S.-F.; Zou, J.-P.; Zhang, W. Asekun, O. 'Mn(OAc)3-Mediated Selective Free Radical Phosphonylation of Pyridinones and Pyrimidinones" Synthesis 2013, 45, 152-1533.
93. Yi, W.-B.; Huang, X.; Cai, C.; Zhang, W. "One-Pot Fluorination Followed by Michael Addition or Robinson Annulation for Preparation of a-Fluorinated Carbonyl Compounds" Green Chem. 2012, 14, 3185-3189.
92. Lu, Q.; Song, G.; Jasinski, J. P.; Keeley, A. C.; Zhang, W. "One-pot double [3+2] Cycloaddition for Diastereoselective Synthesis of Tetracyclic Pyrrolidine Compounds" Green Chem. 2012, 14, 3010-3012.
91. Yi, W.-B.; Huang, X.; Zhang, Z.; Zhu, D.-Z.; Cai, C.; Zhang, W. "Recyclable Fluorous Cinchona Alkaloid Ester as an Organocatalyst for Asymmetric Fluorination of b-Ketoesters" Beilstein J. Org. Chem. 2012, 8, 1233-1240.
90. Zhang, Z.; Kwiatkowski, N.; Zeng, H.; Lim, S. M.; Gray, N. S.; Zhang, W.; Yang, P. L. "Leveraging Kinase Inhibitors to Develop Smalolecule Tools for Imaging Kinases by Fluorescence Microscopy" Mol. BioSystems 2012, 8, 1233-1240.
89. Yi, W.-B., Shi, X.-L., Cai, C., Zhang, W. "Polymer-supported Pd(0) Catalyst for Copper- and Ligand-free Sonogashira Reactions in Aqueous Media" Green Processing and Synth. 2012, 1, 175-180.
88. Zhou, P., Jiang, Y.-J., Zou, J.-P., Zhang, W. "Mn(OAc)3-Mediated Free Radical Phosphonylation of Flavones and Coumarins" Synthesis 2012, 44, 1043-1050.
87. Pan, F.,Chen, T.-M., Cao, J.-J., Zou, J.-P., Zhang, W. "Ga(ClO4)3-Catalyzed Synthesis of Quinoxalines by Cycloaddition of a-Hydroxyketones and O-Phenylenediamines"Tetrahedron Lett. 2012, 53, 2508-2510.
86. Piqani, B.; Zhang, W. "Synthesis of Diverse Dihydropyrimidine-Related Scaffolds by Fluorous Benzaldehyde-Based Biginelli Reaction and Post-Condensation Modifications" Beilstein J. Org. Chem. 2011, 7, 1294-1298.
85. Pan, X.-Q.; Wang, L.; Zou, J.-P.; Zhang, W."Manganese(III)-mediated Phosphinoyl Radical Reactions for Stereoselective Synthesis of Phosphinoylated Tetrahydronaphathalenes" Chem. Commun. 2011, 47, 7875-7877.
84. Zhou, J.; Zhang, G.-L.; Zou, J.-P.; Zhang, W. "Synthesis of Phophonylated and Thiolated Indenones by Manganese(III)-Mediated Addition of Phosphorus- and Sulfur-Centered Radicals to 1,3-Diarylpropynones" Eur. J. Org. Chem. 2011, 3412-3414.
83. Mao, H.-F.; Wang, L.; Zou, J.-P.; Zhang, W. "Lithium Perchlorate-nitromethane (LPNM) Promoted Alkylation of Anilines with Arylmethanols" Mol. Diversity 2011, 15, 849-855.
82. Kadam, A.; Buckley, S. B.; Dinh, T.; Fitzgerald, R.; Zhang, W. "Convertible Fluorous Linker-Assisted Synthesis of Tetrasubstituted Furans" Synlett 2011, 1608-1612.
81. Ding, S.; Le-Nguyen, M., Xu, T.; Zhang, W. "Fluorous Benzaldehyde-based Synthesis of Biaryl-substituted Oxazabicyclo[3.3.1]nonanes" Green Chem. 2011, 13, 847-849.
80. Li, D.-P.; Zhang, G.-L.; An, L.-T.; Zou, J.-P.; Zhang, W. "Solvent- and Catalyst-free Synthesis of 2,3-Dihydro-1H-benzo[d]imidazoles" Green Chem. 2011, 13, 594-597.
79. Lu, Y.; Steven J. Geib, S. J.; Damodaran, K.; Sui, B.; Zhang, Z.; Curran, D. P.; Zhang, W. "Fluorous Diastereomeric Mixture Synthesis (FDMS) of Hydantoin-fused Hexahydrochromeno[4,3-b]pyrroles" Chem. Commun. 2010, 46, 7578-7580.
78. Pan, X.-Q.; Zou, J.-P.; Wang, L.; Zhang, W. "Manganese(III)-Mediated Direct Phosphonation of Arylalkenes and Arylakynes" Chem. Commun. 2010, 46, 1721-1723.
77. Lu, Y.; Nagashima, T.; Miriyala, B.; Conde, J.; Zhang, W. "Fluorous Synthesis of Substituted Sclerotigenin Library" J. Comb. Chem., 2010, 12,125-128.
76. Wang, L.; Cai, C.; Curran, D. P.; Zhang, W. "Enantioselective a-Chlorination of Aldehydes with Recyclable Fluorous (S)-Pyrrolidine-Thiourea Bifunctional Organocatalyst" Synlett 2010, 433-436.
75. Jiang, Y.-J.; Cai, J.-J.; Zou, J.-P.; Zhang, W."Gallium(III) Triflate-Catalyzed [4+2+1] Cycloadditions for Synthesis of Novel 3,4-Disubstituted-1,5-Benzodiazepines" Tetrahedron Lett., 2010, 51,471-474.
74. Zhou, H.; Zhang, W.; Yan, B."Use Cyclohexylisocyanide and Methyl 2-Isocyanoacetate as Convertible Isocyanides for Microwave-Assisted Fluorous Synthesis of 1,4-Benzodiazepine-2,5-dione Library" J. Comb. Chem., 2010, 12,206-214.
73. Liu, A.; Zhou, H.; Su, G.; Zhang, W.; Yan, B."Microwave-Assisted Fluorous Synthesis of 1,4-Benzodiazepine-2,5-dione Library" J. Comb. Chem. 2009, 11, 1083-1093.
72. Damodaran, K.; Nielsen, S. D.; Geib, S. J.; Zhang, W.; Lu, Y.; Curran, D. P. "Aryl-Csp3 bond rotation barriers of 2-aryl perhydropyrrolo[3,4-c]pyrrole-1,3-diones"J. Org. Chem. 2009, 74, 5481-5485.
71. Werner, S.; Nielsen, S. D.; Wipf, P.; Turner, D. M.; Chambers, P. G.; Geib, S. J.; Curran, D. P.; Zhang, W. "Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound library" J. Comb. Chem. 2009, 11, 452-459.
70. Zhang, F.; Zhang, W.; Zhang, Y.; Curran, D. P.; Liu, G. "Synthesis and Applications of Light-Fluorous Glycosyl Donor" J. Org. Chem. 2009, 74, 2594-2597.
69. Pan, X.-Q.; Lei, M.-Y.; Zou, J.-P.; Zhang, W. "Mn(OAc)3-Promoted Regioselective Free Radical Thiocyanation of Indoles and Anilines" Tetrahedron Lett. 2009, 50, 347-349.
68. Cai, J.-J.; Zou,J.-P.; Pan, X. P.; Zhang, W. "Gallium(III) Triflate-catalyzed Synthesis of Quinoxaline Derivatives" Tetrahedron Lett. 2008, 49, 7386-7390.
67. Xu, W.; Zou, J.-P.; Mu, X.-J.; Zhang, W. "Free Radical Ring Expansion and Spirocyclization of 1,3-Diketone derivatives" Tetrahedron Lett. 2008, 49, 7311-7314.
66. Pan, X.-Q.; Zou, J. P.; Huang, Z. H.; Zhang, W. "Ga(OTf)3-Promoted Condensation Reactions for 1,5-Benzodiazepines and 1,5-Benzothiazepines" Tetrahedron Lett. 2008, 49, 5302-5308.
65. Zhou, H.; Aifeng Liu,, Li, X.; Ma, X.; Feng, W.; Zhang, W.; Yan, B. "Microwave-Assisted Fluorous Synthesis of 4-Aryl-substituted Thiazolidinone and Thiazinanone Libraries" J. Comb. Chem. 2008, 10, 303-312.
64. Tonoi, T.; Zhang, W.; Curran, D. P.; Mikami K. "Fluorous Racemic Mixture Synthesis: Polysaccharidebased Chiral Columns for Simultaneous Demix and Enantioseparation of Racemic Fluorous Tagged Compounds" Chirality 2008, 20, 597-603.
63. Lin, M.J.; Zhang, W.; Sun,C.-M. "Fluorous Traceless Synthesis of Substituted Indole Alkaloids" J. Comb. Chem. 2007, 9, 951-958.
62. Zhang, W.; Lu, Y. "96-Well Plate-to-Plate Gravity Fluorous Solid-Phase Extraction (F-SPE) for Solution-Phase Library Purification" J. Comb. Chem. 2007, 9, 836-843.
61. Zhang, W.; Williams, J. A.; Lu, Y.; Nagashima, T.; Chu, Q. "Fluorous Synthesis of Sclerotigenin-Type Benzodiazepine-Quinazolinones" Tetrahedron Lett. 2007, 48, 563-565.
60. Chu, Q.; Zhang, W.; Curran, D. P. "A Recyclable Fluorous Organocatalyst for Diels-Alder Reactions" Tetrahedron Lett. 2006, 47, 9287-9290.
59. Mu, X.-J.; Zou, J.-P.; Qian, Q.-F.; Zhang, W. "Manganese(III) Acetate Promoted Regioselective Phosphonation of Heteroaryl Compounds" Org. Lett. 2006, 8, 5291-5293.
59. Zhang, W.; Lu, Y. "Automation of Fluorous Solid-Phase Extraction for Parallel Synthesis" J. Comb.Chem. 2006, 8, 890-896.
57. Zhang, W.; Lu, Y.; Chen, C. H.-T.; Zeng, L.; Kassel, D. B. "Fluorous Mixture Synthesis of Two Libraries with Hydantoin- and Benzodiazepinedione-Fused Heterocyclic Scaffolds" J. Comb. Chem. 2006, 8, 687-695.
56. Lu, Y.; Zhang, W. "Fluorous 2,4-Dichloro-1,3,5-triazine (F-DCT) for Amine and Thiol Scavenging Reactions" QSAR Comb. Sci. 2006, 25, 728-731.
55. Zhang, W.; Lu, Y. "Fluorous 2,4-Dichloro-1,3,5-triazine (F-DCT) for Amide Coupling Reactions" QSAR Comb. Sci.2006,25, 724-727.
54. Zhang, W.; Lu, Y.; Chen, C. H.-T.; Curran, D. P.; Geib, S. "Fluorous Synthesis of Hydantoin-, Pyrazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems" Eur. J. Org. Chem. 2006, 2055-2059.
53. Zhang, W.; Nagashima, T. "Palladium-Catalyzed Buchwald-Hartwig Type Amination of Fluorous Arylsulfonates" J. Fluorine Chem. 2006, 127, 588-591.
52. Mu, X.-J.; Zou, J.-P.; Qian, Q.-F.; Zhang, W. "Regioselective Synthesis of N-Acetylureas by Manganese(III) Acetate Reaction of 1,3-Disubstituted Thioureas" Tetrahedron Lett. 2006, 47, 2323-2325.
51. Lei, M.-Y.; Mu, X.-J.; Zou, J.-P.; Zhang, W. "Microwave-Assisted Solvent-Free and Catalyst-Free Kabachnik-Fields Reactions for a-Amino Phosphonates" Tetrahedron Lett. 2006, 47, 1125-1127.
50. Chen, C. H.-T.; Zhang, W. "Fluorous Reagents and Scavengers versus Solid-Supported Reagents and Scavengers, a Reaction Rate and Kinetic Comparison" Mol. Diversity 2005, 9, 353-359.
49. Zhang, W.; Lu, Y.; Nagashima, T. "Plate-to-Plate Fluorous Solid-Phase Extraction for Solution-Phase Parallel Synthesis" J.Comb. Chem. 2005, 7, 893-897. Most-Cited Article 2005.
48. Nagashima, T.; Petro, M. J.; Zhang, W. "Fluorous 2-Chloropyridinium Salt (Mukaiyama Condensation Reagent) for Amide Formation Reaction" Tetrahedron Lett. 2005, 6, 6585-6589.
47. Mu, X.-J.; Zou, J.-P.; Wang, Z.-T.; Zhang, W. "Free Radical Ring Expansion and Chain Extension of 1,3-Diketones" Tetrahedron Lett. 2005, 46, 4727-4729.
46. Zhang, W.; Lu, Y.; Geib, S. "Synthesis of Fluorous and Non-Fluorous Polycyclic Systems by One-Pot, Double Intramolecular 1,3-Dipolar Cycloaddition of Azomethine Ylides" Org. Lett. 2005, 7, 2269-2272.
45. Zhang, W.; Chen, C. H.-T. "Fluorous Synthesis of Biaryl-Substituted Prolines by 1,3-Dipolar Cycloaddition and Suzuki Coupling Reactions" Tetrahedron Lett. 2005, 46, 1807-1810.
44. Lu, Y.; Zhang, W. "Fluorous Parallel Synthesis of a Hydantoin/Thiohydantoin Library" Mol. Diversity 2005, 9, 91-98.
43. Nagashima, T.; Zhang W. "Solution-Phase Parallel Synthesis of an N-Alkylated Dihydropteridinone Library" J. Comb. Chem. 2004, 6, 942-949.
42. Lu. Y.; Zhang, W. "Microwave-Assisted Synthesis of a 3-Aminoimidazo[1,2-a]-pyridine/pyrazine Library by Fluorous Multicomponent Rreactions and Subsequent Cross-Coupling Reactions" QSAR Comb. Sci. 2004, 23, 827-835.
41. Zhang, W.; Tempest, P. "Highly Efficient Microwave-Assisted Fluorous Ugi and Post-Condensation Reactions for Benzimidazoles and Quinoxalinones" Tetrahedron Lett. 2004, 45, 6757-6760. Tetrahedron Letters Top 50 most Cited Articles (2004-2007) Award.
40. Zhang, W.; Nagashima, T.; Lu, Y.; Chen, C. H-T. "A Traceless Perfluorooctylsulfonyl Tag for Deoxygenation of Phenols under Microwave Irradiation" Tetrahedron Lett. 2004, 45, 4611-4613.
39. Zhang, W.; Chen, C. H-T.; Lu, Y.; Nagashima, T. "A Highly Efficient Microwave-Assisted Suzuki Coupling Reaction of Aryl Perfluorooctylsulfonates with Boronic Acids" Org. Lett. 2004, 6, 1473-1476.
38. Zhang, W.; Lu, Y.; Chen, C. H-T Combination of Microwave Reactions with Fluorous Separations in the Palladium-Catalyzed Synthesis of Aryl Sulfides Mol. Diversity 2003, 7, 199-202.
37. Zhang, W.; Lu, Y. "Fluorous Synthesis of Hydantoins and Thiohydantoins" Org. Lett. 2003, 5, 2555-2558.
36. Zhang, W.; Pugh, G. "Free Radical Reactions for Heterocycle Synthesis. Part 7: 2-Bromobenzoic Acids as Building Blocks in the Construction of Spiro Compounds" Tetrahedron 2003, 59, 4237-4247.
35. Zhang, W.; Pugh, G. "Free Radical Reactions for Heterocycle Synthesis. Part 6: 2-Bromobenzoic Acids as Building Blocks in the Construction of Nitrogen Heterocycles" Tetrahedron, 2003, 59, 3009-3018.
34. Zhang, W. "Fluorous Synthesis of Disubstituted Pyrimidines" Org. Lett. 2003, 5, 1011-1014.
33. Chen, C. H.-T.; Zhang, W. "FluoMar, a Fluorous Version of the Marshall Resin for Solution-Phase Library Synthesis" Org. Lett. 2003, 5, 1015-1017.
32. Zhang, W.; Chen, C. H.-T.; Nagashima, T. "Fluorous Electrophilic Scavengers for Solution-Phase Parallel Synthesis" Tetrahedron Lett. 2003, 44, 2065-2068.
31. Zhang, W.; Luo, Z.; Chen, H.-T.; Curran, D. P. "Solution-Phase Preparation of A 560-Compound Library of Individually Pure Mappicine Analogs by Fluorous Mixture Synthesis" J. Am. Chem. Soc. 2002, 124, 10443-10450.
30. Zhang, W.; Dennis P. Curran, Christine Chen "Use of Fluorous Silica Gel to Separate Fluorous Thiol Quenching Derivatives in Solution Phase Parallel Synthesis" Tetrahedron 2002, 58, 3871-3876.
29. Zhang, W.; Pugh, G. "Mechanistic Evidence for a Novel Rearrangement Sequence in the Synthesis of 4-Aryl-5,6-dihydro-1,2-oxathiane-2,2-dioxides from Homopropargyl Benzosulfonates" Synlett 2002, 778-780.
28. Zheng, Y.-J., Tao, Y., Zhang, W.; Jordan, D. "Inhibition of Fungal Aldose Reductase" Protein and Peptide Lett. 2001, 8, 407-412.
27. Zhang, W.; Pugh, G. "Free Radical Reactions for Heterocycle Synthesis, Part 5: Formation of Novel Bridged Spirolactones by Double Cyclizations" Tetrahedron Lett. 2001, 42, 5617-5620.
26. Zhang, W.; Pugh, G. "Free Radical Reactions for Heterocycle Synthesis, Part 4: A Double Ipso Substitution Reaction for Azacoumarins" Tetrahedron Lett. 2001, 42, 5613-5615.
25. Zhang, W.; Henry, Y. "A New Synthetic Route to 3,4-Bridged-1,6,6aa4-trithiapentalenes" Synlett 2001, 1129-1130.
24. Zhang, W. "Free Radical Reactions for Heterocycle Synthesis, Part 3: Formation of Novel Spirodilactones and Spirolactone-Lactams and Spirolactone-Thiolactones" Tetrahedron Lett. 2000, 41, 2523-2527.
23. Zhang, W.; Pugh, G. "Free Radical Reactions for Heterocycle Synthesis: Formation of Keto Spiro-a-Lactones and Keto Spiro-a-Lactams" Tetrahedron Lett. 1999, 40, 7595-7598.
22. Zhang, W.; Pugh, G. "Free Radical Reactions for Heterocycle Synthesis: Formation of Tri- and Tetracyclic Isoindolinones" Tetrahedron Lett. 1999, 40, 7591-7594.
21. Zhang, W.; Gorny, R.; Dowd, P. "Formation of 1-Benzosuberones by Three-Carbon Ring Expansion of Benzocyclobutenones" Synth. Commun. 1999, 29, 2903-2913.
20. Curran, P. D.; Gu, X.; Zhang, W.; Dowd, P. "On the Mechanism of the Intermolecular Samarium Barbier Reaction. Probes for Formation of Radical and Organosamarium Intermediates" Tetrahedron 1997, 53, 9023-9042.
19. Zhang, W.; Dowd, P. "Double Ring Expansions: A New Method for Making Medium and Large Cyclic Ketones" Tetrahedron Lett. 1996, 37, 957-960.
18. Zhang, W.; Dowd, P. Free Radical Ring Expansion of Fused-Methylenecyclobutanes Tetrahedron Lett. 1995, 36, 8539-8542.
17. Zhang, W.; Collins, M.; Mahmood, K.; Dowd, P. "Intramolecula [2+2] Cycloaddition and Sequential Ring Expansion" Tetrahedron Lett. 1995, 36, 2729-2732.
16. Dowd, P.; Zhang, W.; Geib, S. J. "Free Radical Annulation of Dichlorocyclobutanones with Sequential Ring Expansion" Tetrahedron 1995, 51, 3435-3454.
15. Dowd, P.; Zhang, W.; Mahmood, K. "Cyclobutanone-Based Tandem Free Radical Rearrangements: Formation of Bicyclic and Tricyclic Ketones" Tetrahedron 1995, 51, 39-50.
14. Zhang, W. "Cyclobutanone-Based Free Radical Free Radical Ring Expansions and Annulations" Dissertation, University of Pittsburgh, 1993. Diss. Abstr. Int. B. 1995, 55, 2740.
13. Zhang, W.; Hua, Y.; Geib, S. J.; Hoge, G.; Dowd, P. Stereoselective Allylation of Dichlorocyclobutanones and Sequential Ring Expansion: Construction of Cis-Fused Cycloheptanones Tetrahedron 1994, 50, 12579-12592.
12. Zhang, W. Hershline, R.; Dowd, P. "A Highly Efficient Preparation of NG-Methyl-L-Arginine and NG-Methyl-D-Arginine" Synth. Commun. 1994, 24, 2789-2792.
11. Dowd, P.; Zhang, W.; Mahmood, K. A. "Cyclobutanone-Based Tandem Free Radical Rearrangement" Tetrahedron Lett. 1994, 35, 5563-5566.
10. Zhang, W.; Dowd, P. "Stereospecific Annulation and Sequential Ring-Opening of (R)-Carvone: Formation of A Novel Tricyclic Dione" Tetrahedron Lett. 1994, 35, 5161-5164.
9. Zhang, W.; Hua, Y.; Hoge, G.; Dowd, P. "Free Radical-Based Annulation of Alkenes Yielding Fused Cycloheptanones" Tetrahedron Lett. 1994, 35, 3865-3868.
8. Dowd, P.; Chang, W.; Partian, C. J.; Zhang, W. "Tetramethyleneethane-d8" J. Phys. Chem. 1993, 97,13408-13412.
7. Zhang, W.; Dowd, P. "Intramolecular Barbier Reaction of a 3-(3'-Bromopropyl)bicyclo[2.2.2]oct-5-en-2-one" Tetrahedron Lett. 1993, 34, 2095-2098.
6. Zhang, W.; Dowd, P. "Free Radical Rearrangement of Bicyclo[2.2.2]- and Bicyclo[4.2.0]octenone Systems" Tetrahedron 1993, 49, 1965-1978.
5. Dowd, P.; Zhang, W. "Free Radical Ring Expansion of Fused Cyclobutanones: Stereospecific Construction of 5,7-, 6,7-, 7,7-, 8,7- and 5,8-Cis-Fused Bicyclic Systems" J. Org. Chem. 1992, 57, 7163-7171.
4. Dowd, P.; Zhang, W. "Novel Free Radical Ring-Formation Reaction of Dichlorocyclobutanones and Sequential Ring Expansion" J. Am. Chem. Soc. 1992, 114, 10084-10085.
3. Zhang, W.; Dowd, P. "Unusual Cyclopropane Formation Following Free Radical Ring Expansion" Tetrahedron Lett. 1992, 33, 7307-7310.
2. Zhang, W.; Dowd, P. "A New Free Radical-Based Method for the Synthesis of Spiroannulated Medium Rings" Tetrahedron Lett. 1992, 33, 3285-3288.
1. Dowd, P.; Zhang, W. "Free Radical Ring Expansion of Fused Cyclobutanones: A New Ring Expansion Annulation Stratagem" J. Am. Chem. Soc. 1991, 113, 9875-9876.
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| Patents and Patent Applications |
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7. Zhang, W.; Zhu, J. "Small Molecule Inhibitors for Transcription Factors", US11,247,996 (2022), WO2018023060A1 (2018).
6. Zhang, W.; Muthengi, A. M. Yosief, H. O. "Certain Imidazopyridines as Cyclic AMP Response Element Binding (CREB) Binding Protein (CBP) Inhibitors and Uses Thereof" US11,098,043 (2021), WO2019014514 (2018).
5. Marineau, J.; Bradner, J.; Zhang, W.; Qi, J.; McKeown, M.; Fu, H.; Liu, S. "Inhibitors of transcription factors and users thereof" US9975896B2 (2018).
4. Zhang, W.; Luo, Z."Fluorous Tagging and Scavenging Reagents and Methods of Synthesis and Use Thereof" US7,576,245 B2 (2009).
3. Zhang, W.; Luo, Z.; Nagashima, T.; Chen, C. H.-T.; Yu, M. S. "Fluorous Tagging and Scavenging Reagents and Methods of Synthesis and Use Thereof" US7,060,850 B2 (2006).
2. Curran, D. P.; Parniak, M. A.; Gabarda, A.; Zhang, W.; Luo, Z.; Chen, C.H.-T. "Preparation of Mappicine Analogs and Intermediates Thereof for Their Therapeutic Use as Antiviral Agents" WO 2003074524 A2 (2003)
1. Zhang, W. "Heterocyclic Herbicides" US5,885,936 (1999).
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