HOME WEI ZHANG GROUP RESEARCH PUBLICATIONS SEMINARS Lab & Equip NEWS Zhang, W. "Fluorous Linker-Facilitated Chemical Synthesis" Chem. Rev. 2009, 109, 749-795. Zhang, W. "Fluorous Synthesis of Heterocyclic Systems" Chem. Rev. 2004, 104, 2531-2556. Dowd, P.; Zhang, W. "Free Radical Mediated Ring Expansion and Related Annulations" Chem. Rev. 1993, 93, 2091-2115. Zhang, W. "Review of Microwave Heating as a Tool for Sustainable Chemistry" J. Am. Chem. Soc. 2011, 133, 3218. Zhang, W.; Luo, Z.; Chen, H.-T.; Curran, D. P. "Solution-Phase Preparation of A 560-Compound Library of Individually Pure Mappicine Analogs by Fluorous Mixture Synthesis" J. Am. Chem. Soc. 2002, 124, 10443-10450. Dowd, P.; Zhang, W. "Novel Free Radical Ring-Formation Reaction of Dichloro-cyclobutanones and Sequential Ring Expansion" J. Am. Chem. Soc. 1992, 114, 10084-10085. Dowd, P.; Zhang, W. "Free Radical Ring Expansion of Fused Cyclobutanones: A New Ring Expansion Annulation Stratagem" J. Am. Chem. Soc. 1991, 113, 9875-9876. Jiang, L.; Yi, W.-B.; Lu, G.; Cai, C.; Zhang, W. "Direct Trifluoromethylthiolation and Perfluoroalkylthiolation of SP2 C-H Bonds with NaSO2CF3 or NaSO2Rf" Angew. Chem. Int. Ed. 2015, 54, 14965-14969. Zhu, J.; Larman, H. B.; Gao, G.; Somwar, R.; Zhang, Z.; Laserson, U; Alberto, C., A.; Pavlova, N.; Church, G.; Zhang, W.; Kesari, S.; Elledge, S. J. "Protein interaction discovery using parallel analysis of translated ORFs (PLato)" Nat. Biotechnol. 2013, 31,331-334. Pan, X.-Q.; Wang, L.; Zou, J.-P.; Zhang, W. "Manganese(III)-mediated Phosphinoyl Radical Reactions for Stereoselective Synthesis of Phosphinoylated Tetrahydronaphathalenes" Chem. Commun. 2011, 47, 7875-7877. Lu, Y.; Geib, S. J.; Damodaran, K.; Sui, B.; Zhang, Z.; Curran, D. P.; Zhang, W. "Fluorous Diastereomeric Mixture Synthesis (FDMS) of Hydantoin-fused Hexahydrochromeno[4,3-b]pyrroles" Chem. Commun. 2010, 46, 7578-7580. Pan, X.-Q.; Zou, J.-P.; Wang, L.; Zhang, W. "Manganese(III)-Mediated Direct Phosphonation of Arylalkenes and Arylakynes" Chem. Commun. 2010, 46, 1721-1723. Zhang, W.; Cai, C. "New Chemical and Biological Applications of Fluorous Technologies" Feature article, Chem. Commun. 2008, 5686-5694. Liu, S.; Yosief, H. O.; Dai, L.; Huang, H.; Dhawan, G.; Zhang, X.; Muthengi, A. M.; Roberts, J.; Buckley, D.; Wu, L.; Bradner, J.; Qi, J.; Zhang, W. "Structure-guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors" J. Med. Chem. 2018, 61, 7785-7795. McKeown, M.; Shaw, D.; Fu, H.; Liu, S.; Xu, X.; Marineau, J.; Huang, Y.; Zhang, X.; Buckley, D.; Lin, C.; Kadam, A.; Zhang, Z.; Blacklow, S.; Qi, J.; Zhang, W.; Bradner, J. "Biased multicomponent reactions to develop novel bromodomain inhibitors" J. Med. Chem. 2014, 57, 9019-9027. Yan, Q.; Jiang, L.; Yi, W.; Liu, Q.; Zhang, W. "Metal-free Difluoromethylthiolation, Trifluoromethylthiolation, and Perfluoroalkylthiolation with HCF2SO2Na, CF3SO2Na or RfSO2Na" Adv. Synth. Catal. 2017, 359, 1919-1926. Huang, X.; Liu, M.; Jasinski, J. P.; Peng, B.; Zhang, W. "Recyclable Organocatalysts for the One-pot Asymmetric Synthesis of 2-Fluorocyclohexanols Bearing Six Contiguous Stereocenters" Adv. Synth. Catal. 2017, 359, 2471-2480. Qian, J.; Yi, W.; Huang, X.; Jasinski, J. P.; Zhang, W. "2,2-Difluoro-1,3-diketones as gem-Difluoroenolate Precusors for Asymmetric Aldol Addition with N-Benzyl Isatins" Adv. Synth. Catal. 2016, 358, 2811-2816. Huang, X.; Pham, K.; Yi, W.; Zhang, X.; Clamens C.; Hyatt, J. P.; Jasinsk, J. P.; Tayvah, U.; Zhang, W. "Recyclable Organocatalyst-promoted One-pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers" Adv. Synth. Catal. 2015, 357, 3820-3824. Vetter, M. L.; Zhang, Z.; Liu, S.; Wang, J.; Cho, H.; Zhang, J.; Zhang, W.; Gray, N. S.; Yang, P. L. "Fluorescent Visualization of Src Using BODIPY-Dasatinib" ChemBioChem 2014, 15, 1317-1324. ZUrick, A.; Hawk, L.; Cassel, M.; Mishra, N.; Adhikari, N.; Liu, S.; Zhang, W.; Hall, J.; Pomerantz, W. "Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules" ACS Chem. Biol. 2015, 10, 2246-2256. Tao, Z.-K.; Li, C.-K.; Zhang, P.-Z.; Zhang L.; Shoberu, A.; Zou, J.-P.; Zhang, W. "Phosphinoyl Radical-initiated 1,2-Bifunctional Thiocyanophosphinoylation of Alkenes" J. Org. Chem. 2018, 83, 2418-2424. Huang, X.; Liu, M.; Pham, K.; Zhang, X.; Yi, W.-B.; Jasinski, J. P.; Zhang, W. "Organocatalytic One-pot Asymmetric Synthesis of Thiolated Spiro-gamma-lactam-oxindoles Bearing Three Stereogenic Centers" J. Org. Chem. 2016, 81, 5362-5369. Li D.-P.; Pan X.-Q.; An, L.-T.; Zou, J.-P.; Zhang, W. "Manganese(III)-mediated Selective Diphenylphosphinoyl Radical Reaction of 1,4-Diphenylbutynes for the Synthesis of Phosphinoylated 3,4-Dihydronaphathalenes" J. Org. Chem. 2014, 79, 1850-1855. Damodaran, K.; Nielsen, S. D.; Geib, S. J.; Zhang, W.; Lu, Y.; Curran, D. P. "Aryl-Csp3 bond rotation barriers of 2-aryl perhydropyrrolo[3,4-c]pyrrole-1,3-diones" J. Org. Chem. 2009, 74, 5481-5485. Zhang, F.; Zhang, W.; Zhang, Y.; Curran, D. P.; Liu, G."Synthesis and Applications of Light-Fluorous Glycosyl Donor" J. Org. Chem. 2009, 74, 2594-2597. Dowd, P.; Zhang, W. "Free Radical Ring Expansion of Fused Cyclobutanones: Stereospecific Construction of 5,7-, 6,7-, 7,7-, 8,7- and 5,8-Cis-Fused Bicyclic Systems" J. Org. Chem. 1992, 57, 7163-7171. Jiang, L.; Ding, D.; Yi, W.; Zeng, X.; Zhang, W. "Fluoroalkylsulfonyl Chlorides-promoted Vicinal Chlorofluoroalkylthiolation of Alkenes and Alkynes" Org. Lett. 2018, 20, 2236-2240. Zhang, P.-Z.; Zhang L.; Li, J.-A.; Shoberu, A.; Zou, J.-P.; Zhang, W. "Phosphinoyl Radical-initiated Vicinal Cyanophosphinoylation of Alkenes" Org. Lett. 2017, 19, 5537-5540. Li, J.-A.; Zhang, P.-Z.; Liu, K.; Shoberu, A.; Zou, J.-P.; Zhang, W. "Phosphinoyl Radical-initiated 1,2-Aminophosphinoylation of Alkenes" Org. Lett. 2017, 19, 4704-4706. Song, Z.; Huang, X.; Yi, W.-B.; Zhang, W. "One-pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridine" Org. Lett. 2016, 18, 5640-5643. Qian, J.; Yi, W.; Huang, X.; Miao, Y.; Zhang, J.; Cai, C.; Zhang, W. "One-Pot Synthesis of 3,5-Disubstituted and Polysubstituted Phenols from Acyclic Precursors" Org. Lett. 2015, 17, 1090-1093. Mu, X.-J.; Zou, J.-P.; Qian, Q.-F.; Zhang, W. Manganese(III) Acetate Promoted Regioselective Phosphonation of Heteroaryl Compounds" Org. Lett. 2006, 8, 5291-5293. Zhang, W.; Lu, Y.; Geib, S. "Synthesis of Fluorous and Non-Fluorous Polycyclic Systems by One-Pot, Double Intramolecular 1,3-Dipolar Cycloaddition of Azomethine Ylides" Org. Lett. 2005, 7, 2269-2272. Zhang, W.; Chen, C. H-T.; Lu, Y.; Nagashima, T. "A Highly Efficient Microwave-Assisted Suzuki Coupling Reaction of Aryl Perfluorooctylsulfonates with Boronic Acids" Org. Lett. 2004, 6, 1473-1476. Chen, C. H.-T.; Zhang, W. "FluoMar, a Fluorous Version of the Marshall Resin for Solution-Phase Library Synthesis" Org. Lett. 2003, 5, 1015-1017. Zhang, W.; Lu, Y. "Fluorous Synthesis of Hydantoins and Thiohydantoins" Org. Lett. 2003, 5, 2555-2558. Zhang, W. "Fluorous Synthesis of Disubstituted Pyrimidines" Org. Lett. 2003, 5, 1011-1014. Muthengi, A.; Zhang, X.; Dhawan, G.; Zhang, W.; Corsini, F.; Zhang, W. "Sequential [3+2] cycloaddition and [5+n] annulation reactions for modular synthesis of dihydrobenzoxazines, tetrahydrobenzoxazepines and tetrahydrobenzoxazocines" Green Chem. 2018, 20, 3134-3139. Zhang, X.; Dhawan, G.; Muthengi, A.; Liu, S.; Wang, W.; Legris, M; Zhang, W. "One-pot and Catalyst-free Synthesis of Pyrroloquinolinediones and Quinolinedicarboxylates" Green Chem. 2017, 19, 3851–3855. Zhang, X.; Zhi, S.; Wang, W.; Liu, S.; Jasinski, J. P.; Zhang, W. "A Pot-economy and Diastereoselective Synthesis Involving Catalyst-free Click Reaction for Fused-triazolobenzodiazepines" Green Chem. 2016, 18, 2642-2646. Kadam, A.; Nguyen, M.; Kopach, M.; Richardson, P.; Gallou, F.; Wan, Z.-K.; Zhang, W. "Comparative Performance Evaluation and Systematic Screening of Solvents in a Range of Grignard Reactions" Green Chem. 2013, 15, 1880-1888. Yi, W.-B.; Huang, X.; Cai, C.; Zhang, W. "One-Pot Fluorination Followed by Michael Addition or Robinson Annulation for Preparation of a-Fluorinated Carbonyl Compounds" Green Chem. 2012, 14, 3185-3189 Lu, Q.; Song, G.; Jasinski, J. P.; Keeley, A. C.; Zhang, W. "One-pot double [3+2] cycloaddition for diastereoselective synthesis of tetracyclic pyrrolidine compounds" Green Chem. 2012, 14, 3010-3012 Ding, S.; Le-Nguyen, M., Xu, T.; Zhang, W. "Fluorous Benzaldehyde-based Synthesis of Biaryl-substituted Oxazabicyclo[3.3.1]nonanes" Green Chem. 2011, 13, 847-849. Li, D.-P.; Zhang, G.-L.; An, L.-T.; Zou, J.-P.; Zhang, W. "Solvent- and Catalyst-free Synthesis of 2,3-Dihydro-1H-benzo[d]imidazoles" Green Chem. 2011, 13, 594-597. Zhang, W. "Green Chemistry Aspects of Fluorous Techniques-Opportunities and Challenges for Small-Scale Organic Synthesis" Critical review article, Green Chem. 2009, 11, 911-920. Pan, X.-Q.; Zou, J.-P.; Yi, W.-B.; Zhang, W. "Recent Advances in Sulfur- and Phosphorous-centered Radical Reactions for the Formation of S-C and P-C Bonds" Tetrahedron 2015, 71, 7481-7529. Zhang, W.; Curran, D. P. "Synthetic applications of fluorous solid-phase extraction (F-SPE)" Tetrahedron 2006, 62, 11837-11865. Zhang, W. "Fluorous Technologies for Solution-Phase High-Throughput Organic Synthesis Tetrahedron 2003, 59, 4475-4489. Zhang, W. "Intramolecular Free Radical Conjugate Additions" Tetrahedron 2001, 57, 7237-7262. Zhang, W.; Pugh, G. "Free Radical Reactions for Heterocycle Synthesis. Part 6: 2-Bromobenzoic Acids as Building Blocks in the Construction of Nitrogen Heterocycles" Tetrahedron, 2003, 59, 3009-3018. Zhang, W.; Dennis P. Curran, Christine Chen "Use of Fluorous Silica Gel to Separate Fluorous Thiol Quenching Derivatives in Solution Phase Parallel Synthesis" Tetrahedron 2002, 58, 3871-3876. Curran, P. D.; Gu, X.; Zhang, W.; Dowd, P. "On the Mechanism of the Intermolecular Samarium Barbier Reaction. Probes for Formation of Radical and Organosamarium Intermediates" Tetrahedron 1997, 53, 9023-9042. Zhou, J.; Zhang, G.-L.; Zou, J.-P.; Zhang, W. "Synthesis of Phophonylated and Thiolated Indenones by Manganese(III)-Mediated Addition of Phosphorus- and Sulfur-Centered Radicals to 1,3-Diarylpropynones" Eur. J. Org. Chem. 2011, 3412-3414. Zhang, W.; Lu, Y.; Chen, C. H.-T.; Curran, D. P.; Geib, S. "Fluorous Synthesis of Hydantoin-, Pyrazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems" Eur. J. Org. Chem. 2006, 2055-2059. Lu, Q.; Huang, X.; Song, G.; Sun, C.-M.; Jasinski, J. P.; Keeley, A. C.; Zhang, W. "Sequential [3+2] and Intramolecular [4+2] Cycloadditions for Stereoselective Synthesis of Novel Polyheterocyclic Compounds" ACS Comb. Sci. 2013, 15, 350-355. Dolle, R, E.; Bourdonnec, B. L.; Worm, K.; Morales, G. A.; Thomas, C. J.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2009" J. Comb. Chem. 2010, 12. 765-806. Lu, Y.; Nagashima, T.; Miriyala, B.; Conde, J.; Zhang, W. "Fluorous Synthesis of Substituted Sclerotigenin Library" J. Comb. Chem. 2010, 12, 125-128. Zhou, H.; Zhang, W.; Yan, B."Use Cyclohexylisocyanide and Methyl 2-Isocyanoacetate as Convertible Isocyanides for Microwave-Assisted Fluorous Synthesis of 1,4-Benzodiazepine-2,5-dione Library" J. Comb. Chem. 2010, 12, 206-214. Werner, S.; Nielsen, S. D.; Wipf, P.; Turner, D. M.; Chambers, P. G.; Geib, S. J.; Curran, D. P.; Zhang, W. "Fluorous Parallel Synthesis of a Piperazinedione-fused Tricyclic Compound Library" J. Comb. Chem. 2009, 11, 452-459. Dolle, R. E.; Bourdonnec, B. L.; Goodman, A. J.; Morales, G. A.; Thomas, C. J.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2008" J. Comb. Chem. 2009, 11, 739-790. Dolle, R. E.; Bourdonnec, B. L.; Goodman, A. J.; Morales, G. A.; Thomas, C. J.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2007" J. Comb. Chem. 2008, 10, 753-802. Dolle, R. E.; Bourdonnec, B. L.; Goodman, A. J.; Morales, G. A.; Salvino, J. M.; Zhang, W. "Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2006" J. Comb. Chem. 2007, 9, 855-902. Lin, M.J.; Zhang, W.; Sun, C.-M. "Fluorous Traceless Synthesis of Substituted Indole Alkaloids" J. Comb. Chem. 2007, 9, 951-958. Zhang, W.; Lu, Y.; Chen, C. H.-T.; Zeng, L.; Kassel, D. B. "Fluorous Mixture Synthesis of Two Libraries with Hydantoin- and Benzodiazepinedione-Fused Heterocyclic Scaffolds" J. Comb. Chem. 2006, 8, 687-695. Zhang, W.; Lu, Y. "Automation of Fluorous Solid-Phase Extraction for Parallel Synthesis" J. Comb. Chem. 2006, 8, 890-896. Zhang, W.; Lu, Y.; Nagashima, T. "Plate-to-Plate Fluorous Solid-Phase Extraction for Solution-Phase Parallel Synthesis" J. Comb. Chem. 2005, 7, 893–897. Nagashima, T.; Zhang W. "Fluorous Parallel Synthesis of an N-Alkylated Dihydropteridinone Library" J. Comb. Chem. 2004, 6, 942-949. Zhang, X.; Liu, M.; Zhang, W.; Legris, M. Zhang, W. "Synthesis of a-Trifluoromethyl Pyrrolidines via A Three-component and Decarboxylative [3+2] Cycloaddition Reaction" J. Fluorine Chem. 2017, 204, 18-20. Yi, W.-B; Ma, J.-J.; Jiang, L.-Q.; Cai, C.; Zhang, W. "Synthesis and Uses of Fluorous and Highly Fluorinated Macrocyclic and Spherical Molecules" J. Fluorine Chem. 2014, 157, 84-105. Zhang, W. "Fluorinated Stationary Phases for HPLC Analysis and Separations" J. Fluorine Chem. 2008, 129, 910-919. Zhang, W.; Nagashima, T. "Palladium-Catalyzed Buchwald-Hartwig Type Amination of Fluorous Arylsulfonates" J. Fluorine Chem. 2006, 127, 588-591. Zhang, W. "Fluorous-Enhanced Multicomponent Reactions for Making Drug-Like Library Scaffolds" Comb. Chem. High Throughput Screening 2007, 10. 219-229. Zhang, W. "Fluorous Chemistry: From Biphasic Catalysis to High-Throughout Synthesis of Small Molecules and Separation/Immobilization of Biomolecules" Editorial, QSAR Comb. Sci. 2006, 25, 679. Lu, Y.; Zhang, W. "Fluorous 2,4-Dichloro-1,3,5-triazine (F-DCT) for amine and thiol scavenging reactions" QSAR Comb. Sci. 2006, 25, 728-731. Zhang, W.; Lu, Y. "Fluorous 2,4-Dichloro-1,3,5-triazine (F-DCT) for Amide Coupling Reactions" QSAR Comb. Sci. 2006, 25, 724-727. Lu. Y.; Zhang, W. "Microwave-Assisted Synthesis of a 3-Aminoimidazo[1,2-a]-pyridine/pyrazine Library by Fluorous Multicomponent Rreactions and Subsequent Cross-Coupling Reactions" QSAR Comb. Sci. 2004, 23, 827-835. Jiang, Z.-X.; Zhi, S.; Zhang, W. "Recent Progresses on Fluorous Synthesis of Biologically Interested Compounds" Mol. Divers. 2014, 18, 203-218. Pan, X.-Q.; Zou, J.-P.; Zhang, W. "Manganese(III)-Promoted Reactions for Formation of Carbon-Heteroatom Bonds" Mol. Divers. 2009, 13, 421-438. Cai, C.; Yi, W.-B.; Zhang, W.; Shen, M.-G.; Hong, M.; Zeng, L. Y. "Fluorous Lewis Acids and Phase Transfer Catalysts" Mol. Divers. 2009, 13, 209-239. Chen, C. H.-T.; Zhang, W. "Fluorous Reagents and Scavengers versus Solid-Supported Reagents and Scavengers, a Reaction Rate and Kinetic Comparison" Mol. Diver. 2005, 9, 353-359. Lu, Y.; Zhang, W. "Fluorous Parallel Synthesis of a Hydantoin/Thiohydantoin Library" Mol. Diversity 2005, 9, 91-98. Zhang, W.; Lu, Y.; Chen, C. H-T "Combination of Microwave Reactions with Fluorous Separations in the Palladium-Catalyzed Synthesis of Aryl Sulfides" Mol. Diver. 2003, 7, 199-202. Zhang, W. "Recent Advance in the Synthesis of Biologically Interesting Heterocycles by Intramolecular Aryl Radical Reactions" Curr. Org. Chem. 2004, 8, 757-780. Zhang, W. "Discovery and Development of Cyclobutanone-Based Ring Expansion and Annulation Reactions" Curr. Org. Chem. 2002, 6, 1015-1029. Zhang, W.; Zhang, X.; Ma, X.; Zhang, W. "One-pot Synthesis of Dihydroquinazolinethione-Based Polycyclic System" Tetrahedron Lett. 2018, in press. An, L.-T.; Cai, J. J.; Pan, X.-Q.; Chen, T.-M.; Zou, J.-P.; Zhang, W. "Ga(DS)3-Catalyzed Double Hydroarylation of Acetylenic Esters with Indoles for The Synthesis of Diindolyl Esters" Tetrahedron Lett. 2015, 56, 3996-3998. Pham, K.; Huang, X.; Zhang, W. "One-Pot Fluorination and Mannich Reactions of 1,3-Dicarbonyl Compounds" Tetrahedron Lett. 2015, 56, 1998-2000. Huang, S.-G.; Mao, H.-F.; Zhou, S.-F.; Zou, J.-P.; Zhang, W. "Recyclable Gallium(III) Triflate-Catalyzed [4+3] Cycloaddition for Synthesis of 2,4-Disubstituted-3H-Benzo[B][1,4]diazepines" Tetrahedron Lett. 2013, 54, 6178-6180. Huang, X.; Yi, W.-B.; Ahad, D.; Zhang, W. "Recyclable Cinchona Alkaloid Catalyzed Asymmetric Michael Addition Reaction" Tetrahedron Lett. 2013, 54, 6064-6066. Pan, F., Chen, T.-M., Cao, J.-J., Zou, J.-P., Zhang, W. "Ga(ClO4)3-Catalyzed Synthesis of Quinoxalines by Cycloaddition of a-Hydroxyketones and O-Phenylenediamines" Tetrahedron Lett. 2012, 53, 2508-2510. Xu, W.; Zou, J.-P.; Zhang, W. "Manganese(III)-Mediated Regioselective Phosphonylation of Arenes” Tetrahedron Lett. 2010, 51, 2639-2643. Jiang, Y.-J.; Cai, J.-J.; Zou, J.-P.; Zhang, W. "Gallium(III) Triflate-Catalyzed [4+2+1] Cycloadditions for Synthesis of Novel 3,4-Disubstituted-1,5-Benzodiazepines" Tetrahedron Lett. 2010, 51, 471-474. Pan, X.-Q.; Lei, M.-Y.; Zou, J.-P.; Zhang, W. "Mn(OAc)3-Promoted Regioselective Free Radical Thiocyanation of Indoles and Anilines" Tetrahedron Lett. 2009, 50, 347-349 . Cai, J.-J.; Zou, J.-P.; Pan, X. P.; Zhang, W. "Gallium(III) triflate-catalyzed synthesis of quinoxaline derivatives" Tetrahedron Lett. 2008, 49, 7386-7390. Xu, W.; Zou, J.-P.; Mu, X.-J.; Zhang, W. "Free Radical Ring Expansion and Spirocyclization of 1,3-Diketone Derivatives" Tetrahedron Lett. 2008, 49, 7311-7314. Pan, X.-Q.; Zou, J. P.; Huang, Z. H.; Zhang, W. "Ga(OTf)3-Promoted condensation reactions for 1,5-benzodiazepines and 1,5-benzothiazepines" Tetrahedron Lett. 2008, 49, 5302-5308. Zhang, W.; Williams, J. P., Lu, Y.; Nagashima, T.; Chu, Q. "Fluorous Synthesis of Sclerotigenin-Type Benzodiazepine-Quinazolinone Library Scaffold" Tetrahedron Lett. 2007, 48, 563-565. Chu, Q.; Zhang, W.; Curran, D. P. "A Recyclab"e Fluorous Organocatalyst for Diels-Alder Reactions" Tetrahedron Lett. 2006, 47, 9287-9290. Lei, M.-Y.; Mu, X.-J.; Zou, J.-P.; Zhang, W. "Microwave-Assisted Solvent-Free and Catalyst-Free Kabachnik-Fields Reactions for ?-Amino Phosphonates" Tetrahedron Lett. 2006, 47, 1125-1127. Nagashima, T.; Petro, M. J.; Zhang, W. "Fluorous 2-Chloropyridinium Salt (Mukaiyama Condensation Reagent) for Amide Formation Reaction" Tetrahedron Lett. 2005, 46, 6585-6589. Zhang, W.; Chen, C. H.-T. "Fluorous Synthesis of Biaryl-Substituted Prolines by 1,3-Dipolar Cycloaddition and Suzuki Coupling Reactions" Tetrahedron Lett. 2005, 46, 1807-1810. Zhang, W.; Tempest, P. "Highly Efficient Microwave-Assisted Fluorous Ugi and Post-Condensation Reactions for Benzimidazoles and Quinoxalinones" Tetrahedron Lett. 2004, 45, 6757-6760. Kadam, A.; Buckley, S. B.; Dinh, T.; Fitzgerald, R.; Zhang, W. "Convertible Fluorous Linker-Assisted Synthesis of Tetrasubstituted Furans" Synlett 2011, 1608-1612. Wang, L.; Cai, C.; Curran, D. P.; Zhang, W. "Enantioselective a-Chlorination of Aldehydes with Recyclable Fluorous (S)-Pyrrolidine-Thiourea Bifunctional Organocatalyst" Synlett 2010, 433-436. Zhang, W.; Pugh, G. "Mechanistic Evidence for a Novel Rearrangement Sequence in the Synthesis of 4-Aryl-5,6-dihydro-1,2-oxathiane-2,2-dioxides from Homopropargyl Benzosulfonates" Synlett 2002, 778-780. Zhang, W.; Henry, Y. "A New Synthetic Route to 3,4-Bridged-1,6,6a4-trithiapentalenes" Synlett 2001, 1129-1130. Zhang, Z.; Kwiatkowski, N.; Zeng, H.; Lim, S. M.; Gray, N. S.; Zhang, W.; Yang, P. L. "Leveraging Kinase Inhibitors to Develop Small Molecule Tools for Imaging Kinases by Fluorescence Microscopy" Mol. BioSystems 2012, 8, 2523-2526. Huang, X.; Pham, K.; Zhang, X.; Yi, W.-B.; Hyatt, J. P.; Tran, A. P.; Jasinski, J. P.; Zhang, W. "Recyclable Organocatalyst-promoted One-pot Michael/aza-Henry/lactamization Sequence for Fluorinated 2-Piperidinones Bearing Four Stereogenic Centers" RSC Advances 2015, 5, 71071-71075. Yi, W.-B.; Zhang, Z.; Huang, X.; Tanner, A.; Cai, C.; Zhang, W. "One-pot Fluorination and Asymmetric Michael Addition Promoted by Recyclable Fluorous Organocatalyst" RSC Advances 2013, 3, 18267-18270. Wang , L.; Wang , J.-W.; Cui, A.-J.; Cai, X.-X.; Wan, Y.; Chen, Q.; He, M.-Y.; Zhang, W. "Regioselective 2,6-Dihalogenation of BODIPYs in HFIP and Preparation of Novel Meso-Alkyl Polymeric BODIPY Dyes" RSC Advances 2013, 3, 9219-9222. Kadam, A.; Zhang, Z.; Zhang, W. "Microwave-Assisted Fluorous Multicomponent Reactions – A Combinatorial Chemistry Approach for Green Organic Synthesis" Curr. Org. Syn. 2011, 8, 295-309. Sun, W. B.; Ji, Y.-F.; Pan, X.-Q.; Zhou, S.-F.; Zou, J.-P.; Zhang, W. Asekun, O. "Mn(OAc)3-Mediated Selective Free Radical Phosphonylation of Pyridinones and Pyrimidinones" Synthesis 2013, 45, 152-1533. Zhou, P., Jiang, Y.-J., Zou, J.-P., Zhang, W. "Mn(OAc)3-Mediated Free Radical Phosphonylation of Flavones and Coumarins" Synthesis 2012, 44,1043-1050. Huang, Y. Zhang, W. "Magnetic nanoparticle-supported organocatalysis" Green Process. Synth. 2013, 2, 603-609. Kadam, A.; Bellinger, S.; Zhang, W. "Atom- and Step-Economic Synthesis of Biaryl Substituted Furocoumarins, Furoquinolones and Furopyrimidines by Multicomponent Reactions and One-Pot Synthesis" Green Process. Synth. 2013, 2, 491-497. Zhang, W. "Laboratory profile of the Green Organic and Medicinal Chemistry at the University of Massachusetts Boston" Green Process. Synth. 2012, 1, 291-293. Yi, W.-B., Shi, X.-L., Cai, C., Zhang, W. "Polymer-supported Pd(0) Catalyst for Copper- and Ligand-free Sonogashira Reactions in Aqueous Media" Green Process. Synth. 2012, 1, 175-180. Zhang, W. "1,3-Dipolar Cycloaddition-Based Synthesis of Diverse Heterocyclic Scaffolds" Chem. Lett. 2013, 42, 676-681. Kadam, A.; Ding, S.; Piqani, B.; Zhang, W. "Fluorous Benzaldehyde as a Convertible Linker for the Synthesis of Heterocyclic Scaffolds" J. Chinese Chem. Soc. 2011, 58, 575-582. Zhang, X.; Pham, K.; Liu, S.; Legris, M.; Muthengi, A.; Jasinski, J. P.; Zhang, W. "Stereoselective Synthesis of Fused-Tetrahydroquinazolines Through One-Pot Double [3+2] Cycloadditions Followed by [5+1] Annulation" Beilstein J. Org. Chem. 2016, 2204-2210. Yi, W.-B.; Huang, X.; Zhang, Z.; Zhu, D.-Z.; Cai, C.; Zhang, W. "Recyclable Fluorous Cinchona Alkaloid Ester as an Organocatalyst for Asymmetric Fluorination of b-Ketoesters" Beilstein J. Org. Chem. 2012, 8, 1233-1240. Piqani, B.; Zhang, W. "Synthesis of Diverse Dihydropyrimidine-Related Scaffolds by Fluorous Benzaldehyde-Based Biginelli Reaction and Post-Condensation Modifications" Beilstein J. Org. Chem. 2011, 7, 1294-1298. Tonoi, T.; Zhang, W.; Curran, D. P.; Mikami K. "Fluorous Racemic Mixture Synthesis: Polysaccharide-based Chiral Columns for Simultaneous Demix and Enantioseparation of Racemic Fluorous Tagged Compounds" Chirality 2008, 20, 597-603. Zhang, W.; Gorny, R.; Dowd, P. "Formation of 1-Benzosuberones by Three-Carbon Ring Expansion of Benzocyclobutenones" Synth. Commun. 1999, 29, 2903-2913. Zhang, W.; Hershline, R.; Dowd, P. "A Highly Efficient Preparation of NG-Methyl-L-Arginine and NG-Methyl-D-Arginine" Synth. Commun. 1994, 24, 2789-2792. Zhang, Z.; Zhang, W. "Fluorous Organocatalysis - A Green Approach for Asymmetric Synthesis" Chimica Oggi (Chemistry Today), 2011, 28 (3), 32-34. Zhang, W. "Microwave-Enhanced Fluorous Synthesis" Chimica Oggi (Chemistry Today) 2005, 23 (3): XI-XIII. Zhang, W. "Fluorous Mixture Syntheses (FMS)" Chimica Oggi (Chemistry Today) 2003, (3/4), 22-24. Todoroki, K.; Ishii, T.; Ide, T.; Min, J. Z.; Inoue, K.; Huang, X.; Zhang, W.; Hamashima, Y.; Toyo’oka, T. "Advanced Dress-up Chiral Columns; Increase of Lineup of Removable Chiral Stationary Phases for Enantioseparation of Chiral Carboxylic Acids" Anal. Chim. Acta 2015, 882, 101-111. Zhang, W., Cue, B. Eds. Green Techniques for Organic Synthesis and Medicinal Chemistry; Wiley, 2012. Zhang, W. "Fluorous Synthesis" book chapter in Green Techniques for Organic Synthesis and Medicinal Chemistry, Zhang, W.; Cue, B. W. Eds., Wiley, Chichester, 2012, p443-468. Zhang, W. "Fluorous Linker-Enabled Organic Synthesis" in Comprehensive Organic Synthesis, 2nd Ed., Molander, G.; Knochel, P. Eds, Elsevier, 2014, pp315-329. Zhang, W.; Lu, Y. "Fluorous Synthesis of 3-Aminoimidazo[1,2-a]-pyridine/pyrazine Library" in Wiley Series on Solid-Phase Organic Synthesis, volume 2: Solid-Phase Palladium Chemistry; Scott, P. Ed. Wiley, 2012, pp51-57. Zhang, W. "Fluorous Linker-facilitated Synthesis of Biologically Interesting Molecules" in Modern Chemoselective Tools for the Synthesis of Complex Bioactive Molecules, Cossy, J.; Arseniyadis, S. Eds. Wiley, 2012, pp349-373. Zhang, W. "Fluorous Organocatalysis" in Fluorous Chemistry, Top. in Curr. Chem. Horvath, I. Ed. Springer, 2012, 308, pp175-190. Mudhoo, A.; Sharma, S. K.; Zhang, W. "Green Chemistry and Engineering: A Versatile Research Perspective", in Green Chemistry for Environmental Sustainability; Mudhoo, A.; Sharma, S. K. Eds., CRC Press Taylor & Francis, 2011, pp1-52. Zhang, W. "Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products" in Fluorine in Medicinal Chemistry and Chemical Biology; Ojima, I. Ed., Wiley-Blackwell, 2009, pp335-359. Zhang, W."Fluorous Linkers" in Linker Strategies in Solid-Phase Organic Synthesis, Scott, P. Ed.; Wiley, 2009, pp553-576. Zhang, W. "Microwave-Enhanced High-Speed Fluorous Synthesis" in Microwave Methods in Organic Synthesis; Topics Curr. Chem. vol. 266, Larhed, M.; Olofsson, K. Eds.; Springer, 2006, pp145-166. Zhang, W. "Fluorous Chemistry for Synthesis and Purification of Biomolecules: Peptides, Oligosacchrades, Glycopeptides, and Oligonucleotides" in ACS Symposium Series: Current Fluoroorganic Chemistry. New Synthetic Directions, Technologies, Materials and Biological Application; Mikami, K.; Soloshonok, V. Eds.; Oxford University Press, 2006, pp 207-220. pp145-166. Zhang, W. "Fluorous Protecting Groups and Tags" in Handbook of Fluorous Chemistry, Gladysz, J. A.; Curran, D. P.; Horvath, I. T. Eds. Wiley-VCH, 2004, pp222-236. Zhang, W. "Synthetically Useful Radical Rearrangements, Ring Expansions" in Radical in Organic Synthesis, vol. 2, Renaud, P.; Sibi, M. P. Eds.; Wiley-VCH, Weinheim, 2001, pp234-245. BACK HOME